By plane
QANTAS provides up to three flights per day from Kingsford Smith International Airport, on Dash 8 or similar Turboprop driven aircraft. The flight to or from Sydney takes about an hour. (http://www.qantas.com.au/)
Virgin Blue operates a low cost service, several flights daily, to and from both Sydney and Brisbane. (http://www.virginblue.com.au/)
Bookings for both can be handled online or at most Qantas offices. During the middle of the year and in holiday times, flights into and out of Port Macquarie are quite easy to get seats on, however, early bookings are highly recommended for flights in school holidays, especially the summer break.
Flights to other regional or capital cities are not currently available directly from Port Macquarie, but connecting flights are very easy to get in Sydney.
By bus
Both Greyhound and Premier Motor Service run multiple daily bus services to and from Port Macquarie to and from Sydney and Brisbane.
Sydney buses arrive and depart Central Railway Station in Central Sydney and take approximately 8 h to travel between Port Macquarie and Sydney. Brisbane buses depart and arrive at the Roma St Transit Centre in Central Brisbane and take approximately 10 h to cover the distance.
In Port Macquarie, all buses drop off at the Port Macquarie Coach Station on the southern side of the Central Business District CBD. The main shopping area is located withing easy walking distance from this station, and some hostels, hotels and a caravan park are located within a distance that you could walk if have not too much luggage. Otherwise, the coach station has a public phone to call a taxi, or hotel for pick up, but most hotel owners and taxi drivers know when the buses arrive and will be waiting for you anyway.
By car
Port Macquarie is located on the Oxley Highway to the east of the Pacific Highway, which is the major north-south highway in NSW.
When travelling from the south Sydney you will see an exit sign pointing to Wauchope/Walcha/Port Macquarie on the left hand side of the road. Take this exit, turn RIGHT at the large roundabout called "The Doughnut" by locals, and follow this road Oxley HWY into all the way into central Port Macquarie where it terminates.
When travelling from the north you will enter an 80 km/h zone and cross the Hastings River over a bridge signposted as Dennis Bridge. After crossing the bridge, the exit is located immediately to the left. Follow this road Hastings River Drive all the way into town.
Note that an alternative route from the south is available which is quite scenic. When travelling from Sydney, turn right at the set of traffic lights in the small town on the highway called Kew. Follow this road for about 10 minutes until you see a sign pointing left saying "Port Macquarie". Follow this road into town.
This route takes aboute 45 min to get to Port Macquarie, but it is worth it for the scenery including North Brother Mountain, Middle Rock Beach and The Christmas Bell Plains. A tourist information board is located in Kew for you to check this route & confirm it before taking it. You should also avoid taking this road after dark, as it is notorious for wildlife on the road, and numerous accidents have been caused by kangaroos.